This collection contains signed letters and manuscripts written by Aldous Huxley between 1916 and 1963. The bulk of the letters were sent to Huxley's friend Robert Nichols, an English poet and dramatist, between 1916 and 1935. The manuscripts included are for the novel Antic Hay, the essay "America and the Future," the book Arabia Infelix and Other Poems, and the poem "Fifth Philosopher's Song, From Leda." The manuscripts for "America and the Future" and Arabia Infelix show Huxley's corrections to his work.

The collection is arranged in two series, one of manuscripts and one of correspondence. The items are arranged chronologically within each box.

Much of Aldous Huxley's personal collection of manuscripts, diaries, and papers were destroyed when his Los Angeles home burned in 1960, enhancing the significance of this collection. Special Collections also houses a large number of Huxley's books, including many first editions and autographed copies.